Correlation Of Neutrophil Lymphocyte Ratio (NLR) and High Sensitivity C-Reactive Protein (hs-CRP) Levels In Patients Coronary Heart Disease (CHD) At Dr. Bratanata Hospital Jambi City

Abstract

Background: Coronary Heart Disease (CHD) is a disorder of heart function caused by reduced blood supply to the heart muscle, resulting in blockage of the coronary arteries due to plaque formation that known as atherosclerosis, this condition is caused by hypercholesterolemia which can induce Granulocyte-Colony Stimulating Factor (G-CSF) so that neutrophil extravasation occurs, a condition of increased neutrophil levels in the body. Increased atherosclerosis leads to apoptosis, resulting in elevated neutrophil levels and reduced lymphocyte levels in the blood, thereby affecting the Neutrophil Lymphocyte Ratio (NLR), which reflects an individual's immune status. Blood cells adhere to form atherosclerotic cell aggregates, stimulating active inflammatory cells. Inflammation can be detected by the biomarker High Sensitivity C-Reactive Protein (Hs-CRP).

Methods: This descriptive-analytic study used a cross-sectional design and population comprised 30 CHD patients at Dr. Bratanata Hospital Jambi. The sample were selected by using purposive sampling, based on inclusion and exclusion criteria. Hs-CRP levels were measured using a Wondfo Meter and NLR was measured using the Mindray Hematology Analyzer. Statistical tests were conducted to determine the relationship between the variables.

Results: The average NLR was 7.82 and also the average Hs-CRP level was 4.94 mg/L. But there was no significant correlation between NLR and Hs-CRP levels in CHD patients. Although the regression plot suggested a possible positive trend but still not statistically significant.

Conclusion: There is no significant correlation between NLR and Hs-CRP levels in CHD patients at Dr. Bratanata Hospital Jambi.