Potential Study of Salivary Total Protein Levels in Patients with Diabetes Mellitus Who Suffer From Pulmonary Tuberculosis in Jambi City

Difa Wigia Hanum; James P. Simanjuntak

doi:10.35910/icohpj.v3i0.889

Difa Wigia Hanum Medical Laboratory Technology Department, Politeknik Kesehatan Kementerian Kesehatan Jambi, Indonesia
James P. Simanjuntak Medical Laboratory Technology Department, Politeknik Kesehatan Kementerian Kesehatan Jambi, Indonesia

DOI: https://doi.org/10.35910/icohpj.v3i0.889

Keywords: DM, DM-TB, Salivary, Total protein levels

Abstract

Background: Diabetes mellitus (DM) is one of the priority non-communicable diseases in Indonesia. DM can occur due to a group of metabolic disorders characterized by hyperglycemia accompanied by metabolic disturbances. Hyperglycaemia in DM will affect total protein levels in the body. Laboratory examinations for the diagnosis of DM can be identified through blood serum. Recent studies have found that total protein can also be identified through other
biological specimens, one of which is saliva. Many complications can be associated with chronic hyperglycemia one of them is Pulmonary Tuberculosis. This study aims to see the potential of salivary total protein levels as an alternative noninvasive
examination in patients with DM-TB.
Method: The study used a case-control and using convenience sampling. The samples of this study were 50 people consisting of 15 DM patients, 20 DM-TB groups, and 15 control. Salivary total protein examination was carried out in Mei-Juni 2024 at Medical Laboratory Technology using a Spectrophotometer (BioSystem BTS New).
Result: The results showed the average total protein level in the three groups is 5.09 mg/dL (salivary) and 7.89 mg/dL (serum). Diagnostic tests carried out by comparing the results of salivary total protein levels in patients with DM-TB with controls showed a sensitivity value of 47% and a specificity of 50%.
Conclusion: Salivary total protein has the potential to be an alternative non-invasive test to differentiate respondents for co-morbidities that as DM-TB.