Study of Albumin Levels in Saliva of Diabetes Mellitus Patients With Pulmonary Tuberculosis

Devi Oktarina Putri; James P. Simanjuntak

doi:10.35910/icohpj.v3i0.890

Devi Oktarina Putri Medical Laboratory Technology Department, Politeknik Kesehatan Kementerian Kesehatan Jambi, Indonesia
James P. Simanjuntak Medical Laboratory Technology Department, Politeknik Kesehatan Kementerian Kesehatan Jambi, Indonesia

DOI: https://doi.org/10.35910/icohpj.v3i0.890

Keywords: Salivary, Albumin, DM-TB, DM

Abstract

Background: Insulin deficiency and/or insulin resistance experienced by patients with DM are known to trigger hypoalbuminemia. Studies have stated the relationship between serum albumin levels and the prediction, prognosis and complications of DM, as well as in
TB where albumin is a marker of nutritional status. From the results of the study it is hoped that it will be able to see a comparison of salivary albumin levels with serum in patients with DM-TB, DM, and controls. As well as knowing whether saliva have the potential to be an alternative prognosis marker in DM patients with TB.
Method: Analytical research was designed using observational methods with a case control approach. 50 respondents who were distinguished based on the status of the respondents.
Result: The results of the examination of saliva and serum specimens showed significant differences in albumin levels from either the DM-TB, DM, or Control groups (P-Value <0.05). In contrast to serum albumin which has decreased, salivary albumin levels were
identified to have increased in DM cases. Where salivary albumin levels in the DM-TB group had the largest mean value compared to the DM and Control groups. This indicates a poor prognosis in patients with DM-TB when compared to other respondent groups.
Conclusion: The mean salivary albumin level was found to be greater in the DM-TB group than the other two groups of respondents. This suggests lower salivary albumin has the potential to indicate the prognosis of DM-TB disease.